trans-5-(3,3,3-Trifluoro-1-propenyl-)-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase

J Med Chem. 1979 Apr;22(4):339-40. doi: 10.1021/jm00190a001.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Deoxyuracil Nucleotides / chemical synthesis*
  • Fluorodeoxyuridylate / analogs & derivatives
  • Fluorodeoxyuridylate / chemical synthesis*
  • Fluorodeoxyuridylate / pharmacology
  • Hydrolysis
  • Kinetics
  • Methyltransferases / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Thymidylate Synthase / antagonists & inhibitors*

Substances

  • Deoxyuracil Nucleotides
  • Fluorodeoxyuridylate
  • Methyltransferases
  • Thymidylate Synthase